AustralieFrV1, Main, Exploration, bibRecord, 007066

Rheumatoid Arthritis: Treatment [151–201]

Identifieur interne : 007066 ( Main/Exploration ); précédent : 007065; suivant : 007067

Rheumatoid Arthritis: Treatment [151–201]

Source :

Rheumatology [ 1462-0324 ] ; 2010-04.

RBID : ISTEX:1A48E2654B0A882B269CADBB1160F59609CCEC35

Abstract

Background: UK guidelines and a `Rheumatology' editorial suggest that liver function tests (LFTs) alone remain a satisfactory method for methotrexate (MTX) monitoring in rheumatoid arthritis (RA). Recent literature also suggests no difference in hepatotoxity between MTX treated RA and psoriatic arthritis (PsA) patients. We describe 3 cases of liver fibrosis / cirrhosis missed by conventional monitoring. Methods: Case 1: 71 yr old female, RA 35 yrs. Presented 2005. Previous breast cancer. Alcohol < 1 unit/week. Rx MTX for 20 years, up to 25mg weekly. Leflunomide (Lef) 10 mg od added 3 mths previously. LFTs normal, P3NP 6.6. 2005-6 RA well controlled, normal LFTs. Repeat P3NP 2006 11.7. Liver ultrasound (US): normal echogenicity and hepatic and portal vein flow. Attempts to stop Lef were unsuccessful and led to use of rescue depomedrone. Developed diabetes. Sept 2007 LFTs normal, albumin 35. Feb 2008: admitted with ascites, ALT 41, albumin 31, bilirubin 24. CT liver normal, US suggested fatty change with normal portal flow. Biopsy showed established cirrhosis on a background of steatohepatitis. MTX and Lef stopped. June 2008: fatal pneumonia. Case 2: 69 yr old male. RA 2007; previous type II diabetes Rx insulin. On simvastatin. Alcohol < 1 unit/week. eGFR 60. LFTs normal. Rx MTX 12.5 mg/week + folic acid. July 2008 ALT 83: MTX ↓ 10 mg, Oct 2008 ALT 89: MTX ↓7.5 mg. Nov 2008 ALT 69. Dec 2008 - Aug 2009 ALT 70, 91, 67, 65, 52 (ie < x2 normal). Aug 2009 ALT 38, alb 27. Sept 2008 ALT 85, albumin 22, INR 1.7.US: shrunken liver. Full liver screen negative. Developed spontaneous bacterial peritonitis. Died Sept 2009. Results: Case 3: 63 yr old female, presented 1999. PsA diagnosed 1993, Rx MTX 7.5mg weekly. Alcohol < 1 unit/week. 1996 ‘routine’ liver biopsy performed (i.e. after 3 yrs MTX), result missing. 1997 US liver normal. Jan 1999: AST 69. Previous liver biopsy retrieved: steatosis + perivascular fibrosis. MTX stopped. LFTs normalized and remain normal. Conclusions: The risk of liver damage in some MTX treated RA and PsA patients may be higher than we think. Patients remain on MTX long term, may resume excess alcohol consumption and may develop concommitant non alcoholic fatty liver disease and steatohepatitis (NAFLD, NASH) during the course of their illness. Polypharmacy (case 1) and diabetes (cases 1 and 2) may be further risk factors. Normal LFTs and US may offer false reasurance. However, minor elevations of liver enzymes may point towards ongoing fibrosis (Case 2). P3NP is used in psoriasis but not in RA because of the confounding factors of disease activity and joint erosion. However, normal values may give some reassurance. US is unreliable as a guide to fibrosis, but more sensitive scans, including Fibroscan, offer promise. Our cases suggest that there may be at risk MTX treated RA and PsA patients who require more detailed liver monitoring. Disclosure statement: All authors have declared no conflicts of interest.

Url:

https://api.istex.fr/document/1A48E2654B0A882B269CADBB1160F59609CCEC35/fulltext/pdf

DOI: 10.1093/rheumatology/keq725

Affiliations:

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<author><name sortKey="Le Bars, Manuela" sort="Le Bars, Manuela" uniqKey="Le Bars M" first="Manuela" last="Le Bars">Manuela Le Bars</name>
</author>
<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
</author>
<author><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R." last="Burmester">Gerd R. Burmester</name>
</author>
<author><name sortKey="Kary, Sonja" sort="Kary, Sonja" uniqKey="Kary S" first="Sonja" last="Kary">Sonja Kary</name>
</author>
<author><name sortKey="Unnebrink, Kristina" sort="Unnebrink, Kristina" uniqKey="Unnebrink K" first="Kristina" last="Unnebrink">Kristina Unnebrink</name>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
</author>
<author><name sortKey="Oezer, Uemit" sort="Oezer, Uemit" uniqKey="Oezer U" first="Uemit" last="Oezer">Uemit Oezer</name>
</author>
<author><name sortKey="Kupper, Hartmut" sort="Kupper, Hartmut" uniqKey="Kupper H" first="Hartmut" last="Kupper">Hartmut Kupper</name>
</author>
<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
</author>
<author><name sortKey="Patra, Kaushik" sort="Patra, Kaushik" uniqKey="Patra K" first="Kaushik" last="Patra">Kaushik Patra</name>
</author>
<author><name sortKey="Lavie, Frederic" sort="Lavie, Frederic" uniqKey="Lavie F" first="Frederic" last="Lavie">Frederic Lavie</name>
</author>
<author><name sortKey="Gasparyan, Armen Y" sort="Gasparyan, Armen Y" uniqKey="Gasparyan A" first="Armen Y." last="Gasparyan">Armen Y. Gasparyan</name>
</author>
<author><name sortKey="Sandoo, Aamer" sort="Sandoo, Aamer" uniqKey="Sandoo A" first="Aamer" last="Sandoo">Aamer Sandoo</name>
</author>
<author><name sortKey="Stavropoulos Kalinoglou, Antonios" sort="Stavropoulos Kalinoglou, Antonios" uniqKey="Stavropoulos Kalinoglou A" first="Antonios" last="Stavropoulos-Kalinoglou">Antonios Stavropoulos-Kalinoglou</name>
</author>
<author><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name>
</author>
<author><name sortKey="Dubash, Sayam R" sort="Dubash, Sayam R" uniqKey="Dubash S" first="Sayam R." last="Dubash">Sayam R. Dubash</name>
</author>
<author><name sortKey="Linton, Stuart" sort="Linton, Stuart" uniqKey="Linton S" first="Stuart" last="Linton">Stuart Linton</name>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
</author>
<author><name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
</author>
<author><name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
</author>
<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
</author>
<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
</author>
<author><name sortKey="Xu, Stephen" sort="Xu, Stephen" uniqKey="Xu S" first="Stephen" last="Xu">Stephen Xu</name>
</author>
<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
</author>
<author><name sortKey="Curtis, Jeffery" sort="Curtis, Jeffery" uniqKey="Curtis J" first="Jeffery" last="Curtis">Jeffery Curtis</name>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
</author>
<author><name sortKey="Mease, Philip" sort="Mease, Philip" uniqKey="Mease P" first="Philip" last="Mease">Philip Mease</name>
</author>
<author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
</author>
<author><name sortKey="Coteur, Geoffroy" sort="Coteur, Geoffroy" uniqKey="Coteur G" first="Geoffroy" last="Coteur">Geoffroy Coteur</name>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
</author>
<author><name sortKey="Van Vollenhoven, Raymond" sort="Van Vollenhoven, Raymond" uniqKey="Van Vollenhoven R" first="Raymond" last="Van Vollenhoven">Raymond Van Vollenhoven</name>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
</author>
<author><name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
</author>
<author><name sortKey="Goel, Niti" sort="Goel, Niti" uniqKey="Goel N" first="Niti" last="Goel">Niti Goel</name>
</author>
<author><name sortKey="Desai, Chintu" sort="Desai, Chintu" uniqKey="Desai C" first="Chintu" last="Desai">Chintu Desai</name>
</author>
<author><name sortKey="Curtis, Jeffery" sort="Curtis, Jeffery" uniqKey="Curtis J" first="Jeffery" last="Curtis">Jeffery Curtis</name>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
</author>
<author><name sortKey="Choy, Ernest" sort="Choy, Ernest" uniqKey="Choy E" first="Ernest" last="Choy">Ernest Choy</name>
</author>
<author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
</author>
<author><name sortKey="Furie, Richard" sort="Furie, Richard" uniqKey="Furie R" first="Richard" last="Furie">Richard Furie</name>
</author>
<author><name sortKey="Blesch, Anne" sort="Blesch, Anne" uniqKey="Blesch A" first="Anne" last="Blesch">Anne Blesch</name>
</author>
<author><name sortKey="Wang, Candace D" sort="Wang, Candace D" uniqKey="Wang C" first="Candace D." last="Wang">Candace D. Wang</name>
</author>
<author><name sortKey="Curtis, Jeffrey R" sort="Curtis, Jeffrey R" uniqKey="Curtis J" first="Jeffrey R." last="Curtis">Jeffrey R. Curtis</name>
</author>
<author><name sortKey="Hughes, Lyndsay D" sort="Hughes, Lyndsay D" uniqKey="Hughes L" first="Lyndsay D." last="Hughes">Lyndsay D. Hughes</name>
</author>
<author><name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
</author>
<author><name sortKey="Done, D John" sort="Done, D John" uniqKey="Done D" first="D. John" last="Done">D. John Done</name>
</author>
<author><name sortKey="Treharne, Gareth" sort="Treharne, Gareth" uniqKey="Treharne G" first="Gareth" last="Treharne">Gareth Treharne</name>
</author>
<author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
</author>
<author><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
</author>
<author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name>
</author>
<author><name sortKey="Macey, Katherine" sort="Macey, Katherine" uniqKey="Macey K" first="Katherine" last="Macey">Katherine Macey</name>
</author>
<author><name sortKey="Sweetster, Marianne T" sort="Sweetster, Marianne T" uniqKey="Sweetster M" first="Marianne T." last="Sweetster">Marianne T. Sweetster</name>
</author>
<author><name sortKey="Lehane, Patricia B" sort="Lehane, Patricia B" uniqKey="Lehane P" first="Patricia B." last="Lehane">Patricia B. Lehane</name>
</author>
<author><name sortKey="Farmer, Pamela" sort="Farmer, Pamela" uniqKey="Farmer P" first="Pamela" last="Farmer">Pamela Farmer</name>
</author>
<author><name sortKey="Long, Simon G" sort="Long, Simon G" uniqKey="Long S" first="Simon G." last="Long">Simon G. Long</name>
</author>
<author><name sortKey="Kremer, Joel M" sort="Kremer, Joel M" uniqKey="Kremer J" first="Joel M." last="Kremer">Joel M. Kremer</name>
</author>
<author><name sortKey="Russell, Anthony S" sort="Russell, Anthony S" uniqKey="Russell A" first="Anthony S." last="Russell">Anthony S. Russell</name>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
</author>
<author><name sortKey="Abud Mendoza, Carlos" sort="Abud Mendoza, Carlos" uniqKey="Abud Mendoza C" first="Carlos" last="Abud-Mendoza">Carlos Abud-Mendoza</name>
</author>
<author><name sortKey="Szechinski, Jacek" sort="Szechinski, Jacek" uniqKey="Szechinski J" first="Jacek" last="Szechinski">Jacek Szechinski</name>
</author>
<author><name sortKey="Becker, Jean Claude" sort="Becker, Jean Claude" uniqKey="Becker J" first="Jean-Claude" last="Becker">Jean-Claude Becker</name>
</author>
<author><name sortKey="Wu, George" sort="Wu, George" uniqKey="Wu G" first="George" last="Wu">George Wu</name>
</author>
<author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Kavanaugh, Arthur" sort="Kavanaugh, Arthur" uniqKey="Kavanaugh A" first="Arthur" last="Kavanaugh">Arthur Kavanaugh</name>
</author>
<author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name>
</author>
<author><name sortKey="Sinisi, Sandra" sort="Sinisi, Sandra" uniqKey="Sinisi S" first="Sandra" last="Sinisi">Sandra Sinisi</name>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
</author>
<author><name sortKey="Strand, V" sort="Strand, V" uniqKey="Strand V" first="V." last="Strand">V. Strand</name>
</author>
<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
</author>
<author><name sortKey="Mease, Philip" sort="Mease, Philip" uniqKey="Mease P" first="Philip" last="Mease">Philip Mease</name>
</author>
<author><name sortKey="Ansari, Zainab" sort="Ansari, Zainab" uniqKey="Ansari Z" first="Zainab" last="Ansari">Zainab Ansari</name>
</author>
<author><name sortKey="Goel, Niti" sort="Goel, Niti" uniqKey="Goel N" first="Niti" last="Goel">Niti Goel</name>
</author>
<author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Desiree" last="Van Der Heijde">Desiree Van Der Heijde</name>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
</author>
<author><name sortKey="Alavi, Azita" sort="Alavi, Azita" uniqKey="Alavi A" first="Azita" last="Alavi">Azita Alavi</name>
</author>
<author><name sortKey="Fitzgerald, Oliver" sort="Fitzgerald, Oliver" uniqKey="Fitzgerald O" first="Oliver" last="Fitzgerald">Oliver Fitzgerald</name>
</author>
<author><name sortKey="Collins, Emily S" sort="Collins, Emily S" uniqKey="Collins E" first="Emily S." last="Collins">Emily S. Collins</name>
</author>
<author><name sortKey="Fraser, Owen" sort="Fraser, Owen" uniqKey="Fraser O" first="Owen" last="Fraser">Owen Fraser</name>
</author>
<author><name sortKey="Tarelli, Edward" sort="Tarelli, Edward" uniqKey="Tarelli E" first="Edward" last="Tarelli">Edward Tarelli</name>
</author>
<author><name sortKey="Ng, Vincent C" sort="Ng, Vincent C" uniqKey="Ng V" first="Vincent C." last="Ng">Vincent C. Ng</name>
</author>
<author><name sortKey="Breshnihan, Barry" sort="Breshnihan, Barry" uniqKey="Breshnihan B" first="Barry" last="Breshnihan">Barry Breshnihan</name>
</author>
<author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J." last="Veale">Douglas J. Veale</name>
</author>
<author><name sortKey="Axford, John S" sort="Axford, John S" uniqKey="Axford J" first="John S." last="Axford">John S. Axford</name>
</author>
<author><name sortKey="Aletaha, D" sort="Aletaha, D" uniqKey="Aletaha D" first="D." last="Aletaha">D. Aletaha</name>
</author>
<author><name sortKey="Alasti, F" sort="Alasti, F" uniqKey="Alasti F" first="F." last="Alasti">F. Alasti</name>
</author>
<author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Schiff, Michael H" sort="Schiff, Michael H" uniqKey="Schiff M" first="Michael H." last="Schiff">Michael H. Schiff</name>
</author>
<author><name sortKey="Rovensky, Josef" sort="Rovensky, Josef" uniqKey="Rovensky J" first="Josef" last="Rovensky">Josef Rovensky</name>
</author>
<author><name sortKey="Taylor, Monet" sort="Taylor, Monet" uniqKey="Taylor M" first="Monet" last="Taylor">Monet Taylor</name>
</author>
<author><name sortKey="John, Ani K" sort="John, Ani K" uniqKey="John A" first="Ani K." last="John">Ani K. John</name>
</author>
<author><name sortKey="Balbir Gurman, Alexandra" sort="Balbir Gurman, Alexandra" uniqKey="Balbir Gurman A" first="Alexandra" last="Balbir-Gurman">Alexandra Balbir-Gurman</name>
</author>
<author><name sortKey="Hughes, Lyndsay D" sort="Hughes, Lyndsay D" uniqKey="Hughes L" first="Lyndsay D." last="Hughes">Lyndsay D. Hughes</name>
</author>
<author><name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
</author>
<author><name sortKey="John Done, D" sort="John Done, D" uniqKey="John Done D" first="D." last="John Done">D. John Done</name>
</author>
<author><name sortKey="Treharne, Gareth J" sort="Treharne, Gareth J" uniqKey="Treharne G" first="Gareth J." last="Treharne">Gareth J. Treharne</name>
</author>
<author><name sortKey="Ezard, Carsten" sort="Ezard, Carsten" uniqKey="Ezard C" first="Carsten" last="Ezard">Carsten Ezard</name>
</author>
<author><name sortKey="Willott, Ruth" sort="Willott, Ruth" uniqKey="Willott R" first="Ruth" last="Willott">Ruth Willott</name>
</author>
<author><name sortKey="Butt, Sayqa" sort="Butt, Sayqa" uniqKey="Butt S" first="Sayqa" last="Butt">Sayqa Butt</name>
</author>
<author><name sortKey="Gadsby, Kate" sort="Gadsby, Kate" uniqKey="Gadsby K" first="Kate" last="Gadsby">Kate Gadsby</name>
</author>
<author><name sortKey="Deighton, Chris" sort="Deighton, Chris" uniqKey="Deighton C" first="Chris" last="Deighton">Chris Deighton</name>
</author>
<author><name sortKey="Tsuru, Tomoni" sort="Tsuru, Tomoni" uniqKey="Tsuru T" first="Tomoni" last="Tsuru">Tomoni Tsuru</name>
</author>
<author><name sortKey="Terao, Kimio" sort="Terao, Kimio" uniqKey="Terao K" first="Kimio" last="Terao">Kimio Terao</name>
</author>
<author><name sortKey="Suzaki, Midori" sort="Suzaki, Midori" uniqKey="Suzaki M" first="Midori" last="Suzaki">Midori Suzaki</name>
</author>
<author><name sortKey="Nakashima, Hitoshi" sort="Nakashima, Hitoshi" uniqKey="Nakashima H" first="Hitoshi" last="Nakashima">Hitoshi Nakashima</name>
</author>
<author><name sortKey="Akiyama, Azusa" sort="Akiyama, Azusa" uniqKey="Akiyama A" first="Azusa" last="Akiyama">Azusa Akiyama</name>
</author>
<author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
</author>
<author><name sortKey="Wordsworth, Paul" sort="Wordsworth, Paul" uniqKey="Wordsworth P" first="Paul" last="Wordsworth">Paul Wordsworth</name>
</author>
<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
</author>
<author><name sortKey="Kay, Jonathon" sort="Kay, Jonathon" uniqKey="Kay J" first="Jonathon" last="Kay">Jonathon Kay</name>
</author>
<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
</author>
<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
</author>
<author><name sortKey="Hsia, Elizabeth" sort="Hsia, Elizabeth" uniqKey="Hsia E" first="Elizabeth" last="Hsia">Elizabeth Hsia</name>
</author>
<author><name sortKey="Zhou, Yiying" sort="Zhou, Yiying" uniqKey="Zhou Y" first="Yiying" last="Zhou">Yiying Zhou</name>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
</author>
<author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
</author>
<author><name sortKey="Siri, Daniel" sort="Siri, Daniel" uniqKey="Siri D" first="Daniel" last="Siri">Daniel Siri</name>
</author>
<author><name sortKey="Furie, Richard" sort="Furie, Richard" uniqKey="Furie R" first="Richard" last="Furie">Richard Furie</name>
</author>
<author><name sortKey="Krasnow, Joel" sort="Krasnow, Joel" uniqKey="Krasnow J" first="Joel" last="Krasnow">Joel Krasnow</name>
</author>
<author><name sortKey="Alecock, Emma" sort="Alecock, Emma" uniqKey="Alecock E" first="Emma" last="Alecock">Emma Alecock</name>
</author>
<author><name sortKey="Alten, Rieke" sort="Alten, Rieke" uniqKey="Alten R" first="Rieke" last="Alten">Rieke Alten</name>
</author>
<author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name>
</author>
<author><name sortKey="Kawata, Yuichi" sort="Kawata, Yuichi" uniqKey="Kawata Y" first="Yuichi" last="Kawata">Yuichi Kawata</name>
</author>
<author><name sortKey="Aoki, Chieko" sort="Aoki, Chieko" uniqKey="Aoki C" first="Chieko" last="Aoki">Chieko Aoki</name>
</author>
<author><name sortKey="Mima, Toru" sort="Mima, Toru" uniqKey="Mima T" first="Toru" last="Mima">Toru Mima</name>
</author>
<author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F." last="Van Vollenhoven">Ronald F. Van Vollenhoven</name>
</author>
<author><name sortKey="Nishimoto, Norihio" sort="Nishimoto, Norihio" uniqKey="Nishimoto N" first="Norihio" last="Nishimoto">Norihio Nishimoto</name>
</author>
<author><name sortKey="Yamanaka, Hisashi" sort="Yamanaka, Hisashi" uniqKey="Yamanaka H" first="Hisashi" last="Yamanaka">Hisashi Yamanaka</name>
</author>
<author><name sortKey="Woodworth, Thasia" sort="Woodworth, Thasia" uniqKey="Woodworth T" first="Thasia" last="Woodworth">Thasia Woodworth</name>
</author>
<author><name sortKey="Schiff, Michael H" sort="Schiff, Michael H" uniqKey="Schiff M" first="Michael H." last="Schiff">Michael H. Schiff</name>
</author>
<author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
</author>
<author><name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E." last="Pope">Janet E. Pope</name>
</author>
<author><name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
</author>
<author><name sortKey="Rubbert, Andrea" sort="Rubbert, Andrea" uniqKey="Rubbert A" first="Andrea" last="Rubbert">Andrea Rubbert</name>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
</author>
<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
</author>
<author><name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
</author>
<author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name>
</author>
<author><name sortKey="Murphy, Frederick T" sort="Murphy, Frederick T" uniqKey="Murphy F" first="Frederick T." last="Murphy">Frederick T. Murphy</name>
</author>
<author><name sortKey="Wu, Zhong" sort="Wu, Zhong" uniqKey="Wu Z" first="Zhong" last="Wu">Zhong Wu</name>
</author>
<author><name sortKey="Parasuraman, Shreekant" sort="Parasuraman, Shreekant" uniqKey="Parasuraman S" first="Shreekant" last="Parasuraman">Shreekant Parasuraman</name>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
</author>
<author><name sortKey="Kay, Jonathan" sort="Kay, Jonathan" uniqKey="Kay J" first="Jonathan" last="Kay">Jonathan Kay</name>
</author>
<author><name sortKey="Wordsworth, Paul" sort="Wordsworth, Paul" uniqKey="Wordsworth P" first="Paul" last="Wordsworth">Paul Wordsworth</name>
</author>
<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
</author>
<author><name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
</author>
<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
</author>
<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
</author>
<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
</author>
<author><name sortKey="Zhou, Yiying" sort="Zhou, Yiying" uniqKey="Zhou Y" first="Yiying" last="Zhou">Yiying Zhou</name>
</author>
<author><name sortKey="Shreekant, Parasuraman" sort="Shreekant, Parasuraman" uniqKey="Shreekant P" first="Parasuraman" last="Shreekant">Parasuraman Shreekant</name>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
</author>
<author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
</author>
<author><name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J. J." last="Gomez-Reino">J. J. Gomez-Reino</name>
</author>
<author><name sortKey="Davies, C" sort="Davies, C" uniqKey="Davies C" first="C." last="Davies">C. Davies</name>
</author>
<author><name sortKey="Alecock, E" sort="Alecock, E" uniqKey="Alecock E" first="E." last="Alecock">E. Alecock</name>
</author>
<author><name sortKey="Rubbert Roth, A" sort="Rubbert Roth, A" uniqKey="Rubbert Roth A" first="A." last="Rubbert-Roth">A. Rubbert-Roth</name>
</author>
<author><name sortKey="Emery, P" sort="Emery, P" uniqKey="Emery P" first="P." last="Emery">P. Emery</name>
</author>
</titleStmt>
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<date when="2010" year="2010">2010</date>
<idno type="doi">10.1093/rheumatology/keq725</idno>
<idno type="url">https://api.istex.fr/document/1A48E2654B0A882B269CADBB1160F59609CCEC35/fulltext/pdf</idno>
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<sourceDesc><biblStruct><analytic><title level="a">Rheumatoid Arthritis: Treatment [151201]</title>
<author><name sortKey="Lloyd, Mark" sort="Lloyd, Mark" uniqKey="Lloyd M" first="Mark" last="Lloyd">Mark Lloyd</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; Gastroenterology, Frimley Park Hospital, Frimley, UK; Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makadsi, Raad" sort="Makadsi, Raad" uniqKey="Makadsi R" first="Raad" last="Makadsi">Raad Makadsi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; Gastroenterology, Frimley Park Hospital, Frimley, UK; Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ala, Aftab" sort="Ala, Aftab" uniqKey="Ala A" first="Aftab" last="Ala">Aftab Ala</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; Gastroenterology, Frimley Park Hospital, Frimley, UK; Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Connor, Patrick" sort="Connor, Patrick" uniqKey="Connor P" first="Patrick" last="Connor">Patrick Connor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; Gastroenterology, Frimley Park Hospital, Frimley, UK; Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gwynne, Catherine" sort="Gwynne, Catherine" uniqKey="Gwynne C" first="Catherine" last="Gwynne">Catherine Gwynne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, University Hospital of Wales, Cardiff, UK; Rheumatology, Princess of Wales Hospital, Bridgend</wicri:regionArea>
<wicri:noRegion>Bridgend</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhys Dillon, Brian" sort="Rhys Dillon, Brian" uniqKey="Rhys Dillon B" first="Brian" last="Rhys Dillon">Brian Rhys Dillon</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, University Hospital of Wales, Cardiff, UK; Rheumatology, Princess of Wales Hospital, Bridgend</wicri:regionArea>
<wicri:noRegion>Bridgend</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lawson, Tom" sort="Lawson, Tom" uniqKey="Lawson T" first="Tom" last="Lawson">Tom Lawson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, University Hospital of Wales, Cardiff, UK; Rheumatology, Princess of Wales Hospital, Bridgend</wicri:regionArea>
<wicri:noRegion>Bridgend</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J." last="Mease">Philip J. Mease</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rubbert Roth, Andrea" sort="Rubbert Roth, Andrea" uniqKey="Rubbert Roth A" first="Andrea" last="Rubbert-Roth">Andrea Rubbert-Roth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Curtis, Jeffrey R" sort="Curtis, Jeffrey R" uniqKey="Curtis J" first="Jeffrey R." last="Curtis">Jeffrey R. Curtis</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gaylis, Norman" sort="Gaylis, Norman" uniqKey="Gaylis N" first="Norman" last="Gaylis">Norman Gaylis</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Gillian K" sort="Armstrong, Gillian K" uniqKey="Armstrong G" first="Gillian K." last="Armstrong">Gillian K. Armstrong</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reynard, Mark" sort="Reynard, Mark" uniqKey="Reynard M" first="Mark" last="Reynard">Mark Reynard</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tyrrell, Helen" sort="Tyrrell, Helen" uniqKey="Tyrrell H" first="Helen" last="Tyrrell">Helen Tyrrell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Leeds General Infirmary, Leeds, UK; Seattle Rheum Assoc, Seattle, WA; University of Cologne, Cologne, Germany; University of Alabama, Birmingham, AL, USA; Kerckhoff Clinic, Bad Nauheim, Germany; Arth Rheum Dis Spec, Aventura, FL, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Joshi, Nilay" sort="Joshi, Nilay" uniqKey="Joshi N" first="Nilay" last="Joshi">Nilay Joshi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology Department, West Suffolk Hospital, Bury St Edmunds, UK; University of East Anglia, Norwich, UK; Rheumatology Department, Norfolk and Norwich University Hospital, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loke, Yoon" sort="Loke, Yoon" uniqKey="Loke Y" first="Yoon" last="Loke">Yoon Loke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology Department, West Suffolk Hospital, Bury St Edmunds, UK; University of East Anglia, Norwich, UK; Rheumatology Department, Norfolk and Norwich University Hospital, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macgregor, Alex" sort="Macgregor, Alex" uniqKey="Macgregor A" first="Alex" last="Macgregor">Alex Macgregor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology Department, West Suffolk Hospital, Bury St Edmunds, UK; University of East Anglia, Norwich, UK; Rheumatology Department, Norfolk and Norwich University Hospital, Norwich</wicri:regionArea>
<wicri:noRegion>Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malaiya, Ritu" sort="Malaiya, Ritu" uniqKey="Malaiya R" first="Ritu" last="Malaiya">Ritu Malaiya</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, East Surrey Hospital, Redhill, UK; Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath</wicri:regionArea>
<wicri:noRegion>Bath</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rachapalli, Satish M" sort="Rachapalli, Satish M" uniqKey="Rachapalli S" first="Satish M." last="Rachapalli">Satish M. Rachapalli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, East Surrey Hospital, Redhill, UK; Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath</wicri:regionArea>
<wicri:noRegion>Bath</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parton, Ted" sort="Parton, Ted" uniqKey="Parton T" first="Ted" last="Parton">Ted Parton</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research DMPK, UCB Celltech, Slough, UK; Clinical Pharmacology, UCB Celltech, Slough, UK; Inflammation Discovery, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="King, Lloyd" sort="King, Lloyd" uniqKey="King L" first="Lloyd" last="King">Lloyd King</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research DMPK, UCB Celltech, Slough, UK; Clinical Pharmacology, UCB Celltech, Slough, UK; Inflammation Discovery, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parker, Gerry" sort="Parker, Gerry" uniqKey="Parker G" first="Gerry" last="Parker">Gerry Parker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research DMPK, UCB Celltech, Slough, UK; Clinical Pharmacology, UCB Celltech, Slough, UK; Inflammation Discovery, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nesbitt, Andrew" sort="Nesbitt, Andrew" uniqKey="Nesbitt A" first="Andrew" last="Nesbitt">Andrew Nesbitt</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research DMPK, UCB Celltech, Slough, UK; Clinical Pharmacology, UCB Celltech, Slough, UK; Inflammation Discovery, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Univ Colorado Sch of Medicine, Denver, CO, USA; Occupational and Industrial Orthopaedic Ctr, Hosp for Joint Disease, NY Univ, NY, USA; Design Research, Smart Design, NY, USA; Device Dev and Industrialization, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sheikzadeh, Ali" sort="Sheikzadeh, Ali" uniqKey="Sheikzadeh A" first="Ali" last="Sheikzadeh">Ali Sheikzadeh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Univ Colorado Sch of Medicine, Denver, CO, USA; Occupational and Industrial Orthopaedic Ctr, Hosp for Joint Disease, NY Univ, NY, USA; Design Research, Smart Design, NY, USA; Device Dev and Industrialization, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Formosa, Dan" sort="Formosa, Dan" uniqKey="Formosa D" first="Dan" last="Formosa">Dan Formosa</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Univ Colorado Sch of Medicine, Denver, CO, USA; Occupational and Industrial Orthopaedic Ctr, Hosp for Joint Disease, NY Univ, NY, USA; Design Research, Smart Design, NY, USA; Device Dev and Industrialization, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Domanska, Barbara" sort="Domanska, Barbara" uniqKey="Domanska B" first="Barbara" last="Domanska">Barbara Domanska</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Univ Colorado Sch of Medicine, Denver, CO, USA; Occupational and Industrial Orthopaedic Ctr, Hosp for Joint Disease, NY Univ, NY, USA; Design Research, Smart Design, NY, USA; Device Dev and Industrialization, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgan, Darrell" sort="Morgan, Darrell" uniqKey="Morgan D" first="Darrell" last="Morgan">Darrell Morgan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Univ Colorado Sch of Medicine, Denver, CO, USA; Occupational and Industrial Orthopaedic Ctr, Hosp for Joint Disease, NY Univ, NY, USA; Design Research, Smart Design, NY, USA; Device Dev and Industrialization, UCB Celltech, Slough</wicri:regionArea>
<wicri:noRegion>Slough</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cifaldi, Mary" sort="Cifaldi, Mary" uniqKey="Cifaldi M" first="Mary" last="Cifaldi">Mary Cifaldi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roy, Sanjoy" sort="Roy, Sanjoy" uniqKey="Roy S" first="Sanjoy" last="Roy">Sanjoy Roy</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Naijun" sort="Chen, Naijun" uniqKey="Chen N" first="Naijun" last="Chen">Naijun Chen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotlieb, Larry" sort="Gotlieb, Larry" uniqKey="Gotlieb L" first="Larry" last="Gotlieb">Larry Gotlieb</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malaise, Michel" sort="Malaise, Michel" uniqKey="Malaise M" first="Michel" last="Malaise">Michel Malaise</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Abbott Laboratories, Abbott Park, IL, USA; Abbott Immunology, Louvain-la-Neuve, Belgium; University Hospital of Liège, Liège</wicri:regionArea>
<wicri:noRegion>Liège</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langtree, Matthew" sort="Langtree, Matthew" uniqKey="Langtree M" first="Matthew" last="Langtree">Matthew Langtree</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lam, Manda" sort="Lam, Manda" uniqKey="Lam M" first="Manda" last="Lam">Manda Lam</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malipeddi, Aruna" sort="Malipeddi, Aruna" uniqKey="Malipeddi A" first="Aruna" last="Malipeddi">Aruna Malipeddi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hassan, Waji" sort="Hassan, Waji" uniqKey="Hassan W" first="Waji" last="Hassan">Waji Hassan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="El Miedany, Yasser" sort="El Miedany, Yasser" uniqKey="El Miedany Y" first="Yasser" last="El Miedany">Yasser El Miedany</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Rheumatology, Darent Valley Hospital, Dartford, UK; Community, Environmental and Occupational Medicine, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="El Gaafary, Maha" sort="El Gaafary, Maha" uniqKey="El Gaafary M" first="Maha" last="El Gaafary">Maha El Gaafary</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Rheumatology, Darent Valley Hospital, Dartford, UK; Community, Environmental and Occupational Medicine, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmer, Deborah" sort="Palmer, Deborah" uniqKey="Palmer D" first="Deborah" last="Palmer">Deborah Palmer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Rheumatology, Darent Valley Hospital, Dartford, UK; Community, Environmental and Occupational Medicine, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dutta, Shouma" sort="Dutta, Shouma" uniqKey="Dutta S" first="Shouma" last="Dutta">Shouma Dutta</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Breslin, Anne" sort="Breslin, Anne" uniqKey="Breslin A" first="Anne" last="Breslin">Anne Breslin</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahmad, Yasmeen" sort="Ahmad, Yasmeen" uniqKey="Ahmad Y" first="Yasmeen" last="Ahmad">Yasmeen Ahmad</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morcos, Peter N" sort="Morcos, Peter N" uniqKey="Morcos P" first="Peter N." last="Morcos">Peter N. Morcos</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Xiaoping" sort="Zhang, Xiaoping" uniqKey="Zhang X" first="Xiaoping" last="Zhang">Xiaoping Zhang</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grange, Susan" sort="Grange, Susan" uniqKey="Grange S" first="Susan" last="Grange">Susan Grange</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schmitt, Christophe" sort="Schmitt, Christophe" uniqKey="Schmitt C" first="Christophe" last="Schmitt">Christophe Schmitt</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malipeddi, Aruna S" sort="Malipeddi, Aruna S" uniqKey="Malipeddi A" first="Aruna S." last="Malipeddi">Aruna S. Malipeddi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neame, Rebecca" sort="Neame, Rebecca" uniqKey="Neame R" first="Rebecca" last="Neame">Rebecca Neame</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D." last="Isaacs">John D. Isaacs</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olech, Ewa" sort="Olech, Ewa" uniqKey="Olech E" first="Ewa" last="Olech">Ewa Olech</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffman La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P." last="Tak">Paul P. Tak</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deodhar, Atul" sort="Deodhar, Atul" uniqKey="Deodhar A" first="Atul" last="Deodhar">Atul Deodhar</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yocum, David" sort="Yocum, David" uniqKey="Yocum D" first="David" last="Yocum">David Yocum</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hessey, Eva" sort="Hessey, Eva" uniqKey="Hessey E" first="Eva" last="Hessey">Eva Hessey</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Read, Simon" sort="Read, Simon" uniqKey="Read S" first="Simon" last="Read">Simon Read</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, UK; Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Rheumatology, Oregon Health and Science University, Portland, OR, USA; Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, Leeds General Infirmary, Leeds, UK; Genentech Inc., South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blunn, Karina J" sort="Blunn, Karina J" uniqKey="Blunn K" first="Karina J." last="Blunn">Karina J. Blunn</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Hereford County Hospital, Hereford, UK; Rheumatology, St Alban's City Hospital, St Alban's</wicri:regionArea>
<wicri:noRegion>St Alban's</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, Richard B" sort="Williams, Richard B" uniqKey="Williams R" first="Richard B." last="Williams">Richard B. Williams</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Hereford County Hospital, Hereford, UK; Rheumatology, St Alban's City Hospital, St Alban's</wicri:regionArea>
<wicri:noRegion>St Alban's</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcdowell, Jackie A" sort="Mcdowell, Jackie A" uniqKey="Mcdowell J" first="Jackie A." last="Mcdowell">Jackie A. Mcdowell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Hereford County Hospital, Hereford, UK; Rheumatology, St Alban's City Hospital, St Alban's</wicri:regionArea>
<wicri:noRegion>St Alban's</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rees, David H" sort="Rees, David H" uniqKey="Rees D" first="David H." last="Rees">David H. Rees</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Hereford County Hospital, Hereford, UK; Rheumatology, St Alban's City Hospital, St Alban's</wicri:regionArea>
<wicri:noRegion>St Alban's</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Hereford County Hospital, Hereford, UK; Rheumatology, St Alban's City Hospital, St Alban's</wicri:regionArea>
<wicri:noRegion>St Alban's</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marks, Jonathan L" sort="Marks, Jonathan L" uniqKey="Marks J" first="Jonathan L." last="Marks">Jonathan L. Marks</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Westlake, Sarah L" sort="Westlake, Sarah L" uniqKey="Westlake S" first="Sarah L." last="Westlake">Sarah L. Westlake</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baird, Janis" sort="Baird, Janis" uniqKey="Baird J" first="Janis" last="Baird">Janis Baird</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kiely, Patrick D" sort="Kiely, Patrick D" uniqKey="Kiely P" first="Patrick D." last="Kiely">Patrick D. Kiely</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ostor, Andrew J" sort="Ostor, Andrew J" uniqKey="Ostor A" first="Andrew J." last="Östör">Andrew J. Östör</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Mark A" sort="Quinn, Mark A" uniqKey="Quinn M" first="Mark A." last="Quinn">Mark A. Quinn</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Peter C" sort="Taylor, Peter C" uniqKey="Taylor P" first="Peter C." last="Taylor">Peter C. Taylor</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Christopher J" sort="Edwards, Christopher J" uniqKey="Edwards C" first="Christopher J." last="Edwards">Christopher J. Edwards</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Southampton University Hospitals NHS Trust, Southampton, UK; Department of Rheumatology, Poole Hospital NHS Foundation Trust, Poole, UK; MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK; Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK; Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Kennedy Institute of Rheumatology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vagadia, Vipul" sort="Vagadia, Vipul" uniqKey="Vagadia V" first="Vipul" last="Vagadia">Vipul Vagadia</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bracewell, Claire" sort="Bracewell, Claire" uniqKey="Bracewell C" first="Claire" last="Bracewell">Claire Bracewell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mckay, Neil" sort="Mckay, Neil" uniqKey="Mckay N" first="Neil" last="Mckay">Neil Mckay</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Collini, Anna" sort="Collini, Anna" uniqKey="Collini A" first="Anna" last="Collini">Anna Collini</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kidd, Elizabeth" sort="Kidd, Elizabeth" uniqKey="Kidd E" first="Elizabeth" last="Kidd">Elizabeth Kidd</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wright, David" sort="Wright, David" uniqKey="Wright D" first="David" last="Wright">David Wright</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watson, Kathryn" sort="Watson, Kathryn" uniqKey="Watson K" first="Kathryn" last="Watson">Kathryn Watson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williams, Emma" sort="Williams, Emma" uniqKey="Williams E" first="Emma" last="Williams">Emma Williams</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mossadegh, Somayyeh" sort="Mossadegh, Somayyeh" uniqKey="Mossadegh S" first="Somayyeh" last="Mossadegh">Somayyeh Mossadegh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ledingham, Joanna" sort="Ledingham, Joanna" uniqKey="Ledingham J" first="Joanna" last="Ledingham">Joanna Ledingham</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwartzman, Sergio" sort="Schwartzman, Sergio" uniqKey="Schwartzman S" first="Sergio" last="Schwartzman">Sergio Schwartzman</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Massarotti, Elena" sort="Massarotti, Elena" uniqKey="Massarotti E" first="Elena" last="Massarotti">Elena Massarotti</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luijtens, Kristel" sort="Luijtens, Kristel" uniqKey="Luijtens K" first="Kristel" last="Luijtens">Kristel Luijtens</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Desiree" last="Van Der Heijde">Desiree Van Der Heijde</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Hospital for Special Surgery, New York, NY, USA; Brigham and Women’s Hospital, Boston, MA, USA; Rebecca MacDonald Ctr for Arth and Autoimmune Dis, Mt Sinai Hospital, Toronto, ON, Canada; Biostatistics, UCB, Braine l’Alleud, Belgium; Department of Rheumatology, Leiden Univ Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kivitz, Alan" sort="Kivitz, Alan" uniqKey="Kivitz A" first="Alan" last="Kivitz">Alan Kivitz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D." last="Isaacs">John D. Isaacs</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stohl, William" sort="Stohl, William" uniqKey="Stohl W" first="William" last="Stohl">William Stohl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P." last="Tak">Paul P. Tak</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jones, Richard" sort="Jones, Richard" uniqKey="Jones R" first="Richard" last="Jones">Richard Jones</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jahreis, Angelika" sort="Jahreis, Angelika" uniqKey="Jahreis A" first="Angelika" last="Jahreis">Angelika Jahreis</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Gillian" sort="Armstrong, Gillian" uniqKey="Armstrong G" first="Gillian" last="Armstrong">Gillian Armstrong</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shaw, Tim" sort="Shaw, Tim" uniqKey="Shaw T" first="Tim" last="Shaw">Tim Shaw</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hôpital Bicêtre, Paris-Sud University, Paris, France; Altoona Osteoporosis Center, Duncansville, PA, USA; Newcastle University, Newcastle upon Tyne, UK; USC, LosAngeles, CA, USA; Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands; Clinic for Rheumatic Diseases, Tuscaloosa, AL, USA; Genentech Inc, South San Francisco, CA, USA; Roche Products Ltd, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strand, Vibeke" sort="Strand, Vibeke" uniqKey="Strand V" first="Vibeke" last="Strand">Vibeke Strand</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Purcaru, Oana" sort="Purcaru, Oana" uniqKey="Purcaru O" first="Oana" last="Purcaru">Oana Purcaru</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kavanaugh, Arthur" sort="Kavanaugh, Arthur" uniqKey="Kavanaugh A" first="Arthur" last="Kavanaugh">Arthur Kavanaugh</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dept Rheumatology, Univ Hospital KU Leuven, Leuven, Belgium; Div Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; Outcomes and Access Immunology, UCB, Brussels, Belgium; Dept Rheumatology, UCLA, Los Angeles, CA, USA; Div Rheumatology, Univ of Vienna, Vienna, Austria; Div Rheum, UCSD, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Baldassare, Andrew R" sort="Baldassare, Andrew R" uniqKey="Baldassare A" first="Andrew R." last="Baldassare">Andrew R. Baldassare</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Armstrong, Gillian K" sort="Armstrong, Gillian K" uniqKey="Armstrong G" first="Gillian K." last="Armstrong">Gillian K. Armstrong</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Linnik, Matthew" sort="Linnik, Matthew" uniqKey="Linnik M" first="Matthew" last="Linnik">Matthew Linnik</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Reynard, Mark" sort="Reynard, Mark" uniqKey="Reynard M" first="Mark" last="Reynard">Mark Reynard</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Tyrrell, Helen" sort="Tyrrell, Helen" uniqKey="Tyrrell H" first="Helen" last="Tyrrell">Helen Tyrrell</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center, Dallas, TX, USA; Leeds General Infirmary, Leeds, UK; Hôpital Cochin, Paris, France; St Louis University, St Louis, MO, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Toronto</settlement>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Mcinnes, Iain B" sort="Mcinnes, Iain B" uniqKey="Mcinnes I" first="Iain B." last="Mcinnes">Iain B. Mcinnes</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Rheumatic Diseases, University of Glasgow, Glasgow, UK; Immuno-rheumatology Division, Hopital Lapeyronie, Montpellier University Hospital, Montpellier, France; Rheumatology and Clinical Immunology, Charite University Hospital, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
<settlement type="city">Glasgow</settlement>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Rheumatic Diseases, University of Glasgow, Glasgow, UK; Immuno-rheumatology Division, Hopital Lapeyronie, Montpellier University Hospital, Montpellier, France; Rheumatology and Clinical Immunology, Charite University Hospital, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
<settlement type="city">Glasgow</settlement>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Burmester, Gerd" sort="Burmester, Gerd" uniqKey="Burmester G" first="Gerd" last="Burmester">Gerd Burmester</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Rheumatic Diseases, University of Glasgow, Glasgow, UK; Immuno-rheumatology Division, Hopital Lapeyronie, Montpellier University Hospital, Montpellier, France; Rheumatology and Clinical Immunology, Charite University Hospital, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
<settlement type="city">Glasgow</settlement>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keiserman, Mauro" sort="Keiserman, Mauro" uniqKey="Keiserman M" first="Mauro" last="Keiserman">Mauro Keiserman</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Codding, Christine" sort="Codding, Christine" uniqKey="Codding C" first="Christine" last="Codding">Christine Codding</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Songcharoen, Suthin" sort="Songcharoen, Suthin" uniqKey="Songcharoen S" first="Suthin" last="Songcharoen">Suthin Songcharoen</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berman, Alberto" sort="Berman, Alberto" uniqKey="Berman A" first="Alberto" last="Berman">Alberto Berman</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nayiager, Sauithree" sort="Nayiager, Sauithree" uniqKey="Nayiager S" first="Sauithree" last="Nayiager">Sauithree Nayiager</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saldate, Cristina" sort="Saldate, Cristina" uniqKey="Saldate C" first="Cristina" last="Saldate">Cristina Saldate</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aranda, Richard" sort="Aranda, Richard" uniqKey="Aranda R" first="Richard" last="Aranda">Richard Aranda</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Jean Claude" sort="Becker, Jean Claude" uniqKey="Becker J" first="Jean-Claude" last="Becker">Jean-Claude Becker</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Cathy" sort="Zhao, Cathy" uniqKey="Zhao C" first="Cathy" last="Zhao">Cathy Zhao</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Bars, Manuela" sort="Le Bars, Manuela" uniqKey="Le Bars M" first="Manuela" last="Le Bars">Manuela Le Bars</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Colorado, Denver, CO, USA; Pontificial Catholic University, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis and Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del Noroeste, Tijuan, Mexico; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Rueil-Malmaison, France; Hopital Cochin, Descartes University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R." last="Burmester">Gerd R. Burmester</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kary, Sonja" sort="Kary, Sonja" uniqKey="Kary S" first="Sonja" last="Kary">Sonja Kary</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Unnebrink, Kristina" sort="Unnebrink, Kristina" uniqKey="Unnebrink K" first="Kristina" last="Unnebrink">Kristina Unnebrink</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oezer, Uemit" sort="Oezer, Uemit" uniqKey="Oezer U" first="Uemit" last="Oezer">Uemit Oezer</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kupper, Hartmut" sort="Kupper, Hartmut" uniqKey="Kupper H" first="Hartmut" last="Kupper">Hartmut Kupper</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Charité-University Medicine Berlin, Berlin, Germany; Abbott GmbH and Co. KG, Ludwigshafen, Germany; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Paris V, Cochin Hospital, Paris, France; University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; Abbott Laboratories, Rungis, France; Abbott Laboratories, Abbott Park, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Paris V, Cochin Hospital, Paris, France; University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; Abbott Laboratories, Rungis, France; Abbott Laboratories, Abbott Park, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Paris V, Cochin Hospital, Paris, France; University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; Abbott Laboratories, Rungis, France; Abbott Laboratories, Abbott Park, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Patra, Kaushik" sort="Patra, Kaushik" uniqKey="Patra K" first="Kaushik" last="Patra">Kaushik Patra</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Paris V, Cochin Hospital, Paris, France; University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; Abbott Laboratories, Rungis, France; Abbott Laboratories, Abbott Park, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lavie, Frederic" sort="Lavie, Frederic" uniqKey="Lavie F" first="Frederic" last="Lavie">Frederic Lavie</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Paris V, Cochin Hospital, Paris, France; University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; Abbott Laboratories, Rungis, France; Abbott Laboratories, Abbott Park, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gasparyan, Armen Y" sort="Gasparyan, Armen Y" uniqKey="Gasparyan A" first="Armen Y." last="Gasparyan">Armen Y. Gasparyan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sandoo, Aamer" sort="Sandoo, Aamer" uniqKey="Sandoo A" first="Aamer" last="Sandoo">Aamer Sandoo</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stavropoulos Kalinoglou, Antonios" sort="Stavropoulos Kalinoglou, Antonios" uniqKey="Stavropoulos Kalinoglou A" first="Antonios" last="Stavropoulos-Kalinoglou">Antonios Stavropoulos-Kalinoglou</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dubash, Sayam R" sort="Dubash, Sayam R" uniqKey="Dubash S" first="Sayam R." last="Dubash">Sayam R. Dubash</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Linton, Stuart" sort="Linton, Stuart" uniqKey="Linton S" first="Stuart" last="Linton">Stuart Linton</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Xu, Stephen" sort="Xu, Stephen" uniqKey="Xu S" first="Stephen" last="Xu">Stephen Xu</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Leeds, Leeds, UK; Stanford University, Palo Alto, CA; University of Texas Southwestern Medical Center, Dallas, TX, USA; Mayo Clinic, Rochester, MN, USA; Centocor Research and Development, Inc., Malvern, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Leeds</settlement>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Curtis, Jeffery" sort="Curtis, Jeffery" uniqKey="Curtis J" first="Jeffery" last="Curtis">Jeffery Curtis</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mease, Philip" sort="Mease, Philip" uniqKey="Mease P" first="Philip" last="Mease">Philip Mease</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coteur, Geoffroy" sort="Coteur, Geoffroy" uniqKey="Coteur G" first="Geoffroy" last="Coteur">Geoffroy Coteur</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Rebecca MacDonald Ctr for Arthritis and Autoimmune Diseases, Mt Sinai Hospital, Toronto, ON, Canada; University of Alabama, Birmingham, AL; University of Texas, Dallas, TX, USA; Seattle Rheumatology Associates, Seattle, WA, USA; UCLA, Los Angeles, CA, USA; Medical University of Vienna, Vienna, Austria; Outcomes and Access - Immunology, UCB Pharma, Brussels, Belgium; Hospital Lapeyronie, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Raymond" sort="Van Vollenhoven, Raymond" uniqKey="Van Vollenhoven R" first="Raymond" last="Van Vollenhoven">Raymond Van Vollenhoven</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goel, Niti" sort="Goel, Niti" uniqKey="Goel N" first="Niti" last="Goel">Niti Goel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Desai, Chintu" sort="Desai, Chintu" uniqKey="Desai C" first="Chintu" last="Desai">Chintu Desai</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Curtis, Jeffery" sort="Curtis, Jeffery" uniqKey="Curtis J" first="Jeffery" last="Curtis">Jeffery Curtis</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choy, Ernest" sort="Choy, Ernest" uniqKey="Choy E" first="Ernest" last="Choy">Ernest Choy</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Rheumatology, Medical University of Vienna, Vienna, Austria; Rheumatology Division, School of Medicine, University of Colorado, Denver, CO, USA; MCRC, University of Texas, Dallas, TX, USA; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Global Projects and Development, UCB, Smyrna, Georgia, USA; Biostatistics, UCB, Slough, UK; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mt Sinai Hospital, Toronto, ON, Canada; Department of Rheumatology, University of Leeds, Leeds, UK; Department of Rheumatology, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furie, Richard" sort="Furie, Richard" uniqKey="Furie R" first="Richard" last="Furie">Richard Furie</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blesch, Anne" sort="Blesch, Anne" uniqKey="Blesch A" first="Anne" last="Blesch">Anne Blesch</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Candace D" sort="Wang, Candace D" uniqKey="Wang C" first="Candace D." last="Wang">Candace D. Wang</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Curtis, Jeffrey R" sort="Curtis, Jeffrey R" uniqKey="Curtis J" first="Jeffrey R." last="Curtis">Jeffrey R. Curtis</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Karolinska University Hospital, Stockholm, Sweden; University of Toronto, Toronto, ON, Canada; ND-LIJ Health System, Lake Success, NY, USA; F. Hoffman La Roche, Nutley, NJ, USA; University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Lyndsay D" sort="Hughes, Lyndsay D" uniqKey="Hughes L" first="Lyndsay D." last="Hughes">Lyndsay D. Hughes</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Done, D John" sort="Done, D John" uniqKey="Done D" first="D. John" last="Done">D. John Done</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Treharne, Gareth" sort="Treharne, Gareth" uniqKey="Treharne G" first="Gareth" last="Treharne">Gareth Treharne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macey, Katherine" sort="Macey, Katherine" uniqKey="Macey K" first="Katherine" last="Macey">Katherine Macey</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sweetster, Marianne T" sort="Sweetster, Marianne T" uniqKey="Sweetster M" first="Marianne T." last="Sweetster">Marianne T. Sweetster</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lehane, Patricia B" sort="Lehane, Patricia B" uniqKey="Lehane P" first="Patricia B." last="Lehane">Patricia B. Lehane</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Farmer, Pamela" sort="Farmer, Pamela" uniqKey="Farmer P" first="Pamela" last="Farmer">Pamela Farmer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Long, Simon G" sort="Long, Simon G" uniqKey="Long S" first="Simon G." last="Long">Simon G. Long</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Karolinska Institute, Stockholm, Sweden; Leeds General Infirmary, Leeds, UK; Johns Hopkins University, Baltimore, MD, USA; University of Toronto, Toronto, ON, Canada; University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; UCLA, Los Angeles, CA, USA; Roche Products Ltd, Welwyn Garden City, UK; Biogen Idec Inc, Cambridge, MD, USA; Genentech, Inc., South San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremer, Joel M" sort="Kremer, Joel M" uniqKey="Kremer J" first="Joel M." last="Kremer">Joel M. Kremer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Russell, Anthony S" sort="Russell, Anthony S" uniqKey="Russell A" first="Anthony S." last="Russell">Anthony S. Russell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abud Mendoza, Carlos" sort="Abud Mendoza, Carlos" uniqKey="Abud Mendoza C" first="Carlos" last="Abud-Mendoza">Carlos Abud-Mendoza</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szechinski, Jacek" sort="Szechinski, Jacek" uniqKey="Szechinski J" first="Jacek" last="Szechinski">Jacek Szechinski</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Becker, Jean Claude" sort="Becker, Jean Claude" uniqKey="Becker J" first="Jean-Claude" last="Becker">Jean-Claude Becker</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, George" sort="Wu, George" uniqKey="Wu G" first="George" last="Wu">George Wu</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name>
<affiliation wicri:level="1"><country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Rheumatology, Albany Medical College, Albany, NY, USA; University of Alberta Hospital, Edmonton, AB, Canada; University of Leeds, Leeds, UK; Rheumatology Hospital, San Luis Potosi, Mexico; Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland; Bristol-Myers Squibb, Princeton, NJ; Bristol-Myers Squibb, Plainsboro, NJ, USA; UZ Gasthuisberg, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; University of California, San Diego, CA, USA; Leiden University Medical Center, Leiden, Netherlands; Abbott Laboratories, Abbott Park, IL, USA; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kavanaugh, Arthur" sort="Kavanaugh, Arthur" uniqKey="Kavanaugh A" first="Arthur" last="Kavanaugh">Arthur Kavanaugh</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; University of California, San Diego, CA, USA; Leiden University Medical Center, Leiden, Netherlands; Abbott Laboratories, Abbott Park, IL, USA; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; University of California, San Diego, CA, USA; Leiden University Medical Center, Leiden, Netherlands; Abbott Laboratories, Abbott Park, IL, USA; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sinisi, Sandra" sort="Sinisi, Sandra" uniqKey="Sinisi S" first="Sandra" last="Sinisi">Sandra Sinisi</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; University of California, San Diego, CA, USA; Leiden University Medical Center, Leiden, Netherlands; Abbott Laboratories, Abbott Park, IL, USA; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>University of Toronto-Mount Sinai Hospital, Toronto, ON, Canada; University of California, San Diego, CA, USA; Leiden University Medical Center, Leiden, Netherlands; Abbott Laboratories, Abbott Park, IL, USA; Abbott Laboratories, Rungis</wicri:regionArea>
<wicri:noRegion>Rungis</wicri:noRegion>
<wicri:noRegion>Rungis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fleischmann, Roy" sort="Fleischmann, Roy" uniqKey="Fleischmann R" first="Roy" last="Fleischmann">Roy Fleischmann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strand, V" sort="Strand, V" uniqKey="Strand V" first="V." last="Strand">V. Strand</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mease, Philip" sort="Mease, Philip" uniqKey="Mease P" first="Philip" last="Mease">Philip Mease</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ansari, Zainab" sort="Ansari, Zainab" uniqKey="Ansari Z" first="Zainab" last="Ansari">Zainab Ansari</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goel, Niti" sort="Goel, Niti" uniqKey="Goel N" first="Niti" last="Goel">Niti Goel</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Desiree" last="Van Der Heijde">Desiree Van Der Heijde</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rebecca MacDonald Centre for Arthritis and Autoimmune Disorders, Mt Sinai Hospital, Toronto, ON, Canada; MCRC, Univ of Texas, Dallas, TX, USA; Div of Rheum, Univ of Vienna, Vienna, Austria; Div of Immunol/Rheumatol, Stanford Univ, Palo Alto, CA, USA; Div of Rheum, Univ Hospital Maastricht, Maastricht, Netherlands; Immuno-Rheumatologie, Hospital Lapeyronie, Montpellier, France; Seattle Rheum Associates, Seattle, WA, USA; Biostatistics, UCB, Slough, UK; UCB, Smyrna, GA; Dept of Rheum, Leiden Univ Medical Center, Leiden, Netherlands; University of Leeds, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alavi, Azita" sort="Alavi, Azita" uniqKey="Alavi A" first="Azita" last="Alavi">Azita Alavi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fitzgerald, Oliver" sort="Fitzgerald, Oliver" uniqKey="Fitzgerald O" first="Oliver" last="Fitzgerald">Oliver Fitzgerald</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Collins, Emily S" sort="Collins, Emily S" uniqKey="Collins E" first="Emily S." last="Collins">Emily S. Collins</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fraser, Owen" sort="Fraser, Owen" uniqKey="Fraser O" first="Owen" last="Fraser">Owen Fraser</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tarelli, Edward" sort="Tarelli, Edward" uniqKey="Tarelli E" first="Edward" last="Tarelli">Edward Tarelli</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ng, Vincent C" sort="Ng, Vincent C" uniqKey="Ng V" first="Vincent C." last="Ng">Vincent C. Ng</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Breshnihan, Barry" sort="Breshnihan, Barry" uniqKey="Breshnihan B" first="Barry" last="Breshnihan">Barry Breshnihan</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Veale, Douglas J" sort="Veale, Douglas J" uniqKey="Veale D" first="Douglas J." last="Veale">Douglas J. Veale</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Axford, John S" sort="Axford, John S" uniqKey="Axford J" first="John S." last="Axford">John S. Axford</name>
<affiliation wicri:level="4"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London, London, UK; Biomics, St George's University of London, London, UK; Rheumatology, St Vincents University Hospital, Dublin</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aletaha, D" sort="Aletaha, D" uniqKey="Aletaha D" first="D." last="Aletaha">D. Aletaha</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alasti, F" sort="Alasti, F" uniqKey="Alasti F" first="F." last="Alasti">F. Alasti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schiff, Michael H" sort="Schiff, Michael H" uniqKey="Schiff M" first="Michael H." last="Schiff">Michael H. Schiff</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rovensky, Josef" sort="Rovensky, Josef" uniqKey="Rovensky J" first="Josef" last="Rovensky">Josef Rovensky</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Monet" sort="Taylor, Monet" uniqKey="Taylor M" first="Monet" last="Taylor">Monet Taylor</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="John, Ani K" sort="John, Ani K" uniqKey="John A" first="Ani K." last="John">Ani K. John</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balbir Gurman, Alexandra" sort="Balbir Gurman, Alexandra" uniqKey="Balbir Gurman A" first="Alexandra" last="Balbir-Gurman">Alexandra Balbir-Gurman</name>
<affiliation wicri:level="4"><country xml:lang="fr">Israël</country>
<wicri:regionArea>University of Toronto, Toronto, ON, Canada; University of Colorado, Denver, CO, USA; National Institue of Rheumatic Diseases, Piestany, Slovakia; F. Hoffmann-La Roche, Nutley, NJ, USA; Rambam Health Care Center, Haifa</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Lyndsay D" sort="Hughes, Lyndsay D" uniqKey="Hughes L" first="Lyndsay D." last="Hughes">Lyndsay D. Hughes</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="John Done, D" sort="John Done, D" uniqKey="John Done D" first="D." last="John Done">D. John Done</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Treharne, Gareth J" sort="Treharne, Gareth J" uniqKey="Treharne G" first="Gareth J." last="Treharne">Gareth J. Treharne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>CLiCIR, University of Hertfordshire, Hatfield, UK; ERAS, Rheumatology, City Hospital, St Albans, UK; Psychology, University of Otago, Dunedin 9054</wicri:regionArea>
<wicri:noRegion>Dunedin 9054</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ezard, Carsten" sort="Ezard, Carsten" uniqKey="Ezard C" first="Carsten" last="Ezard">Carsten Ezard</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Willott, Ruth" sort="Willott, Ruth" uniqKey="Willott R" first="Ruth" last="Willott">Ruth Willott</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Butt, Sayqa" sort="Butt, Sayqa" uniqKey="Butt S" first="Sayqa" last="Butt">Sayqa Butt</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gadsby, Kate" sort="Gadsby, Kate" uniqKey="Gadsby K" first="Kate" last="Gadsby">Kate Gadsby</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deighton, Chris" sort="Deighton, Chris" uniqKey="Deighton C" first="Chris" last="Deighton">Chris Deighton</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Rheumatology, Frimley Park Hospital, Frimley, UK; 2Gastroenterology, Frimley Park Hospital, Frimley, UK; 3Rheumatology, East Surrey Hospital, Redhill</wicri:regionArea>
<wicri:noRegion>Redhill</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsuru, Tomoni" sort="Tsuru, Tomoni" uniqKey="Tsuru T" first="Tomoni" last="Tsuru">Tomoni Tsuru</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Terao, Kimio" sort="Terao, Kimio" uniqKey="Terao K" first="Kimio" last="Terao">Kimio Terao</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suzaki, Midori" sort="Suzaki, Midori" uniqKey="Suzaki M" first="Midori" last="Suzaki">Midori Suzaki</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nakashima, Hitoshi" sort="Nakashima, Hitoshi" uniqKey="Nakashima H" first="Hitoshi" last="Nakashima">Hitoshi Nakashima</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akiyama, Azusa" sort="Akiyama, Azusa" uniqKey="Akiyama A" first="Azusa" last="Akiyama">Azusa Akiyama</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>PS Clinic, Medical Co. Ltd, Fukuoka, Japan; Clinicalpharmacology, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan; Fukuoka University, Fukuoka, Japan; Chugai Clinical Research Center Co., Ltd, Tokyo, Japan; Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wordsworth, Paul" sort="Wordsworth, Paul" uniqKey="Wordsworth P" first="Paul" last="Wordsworth">Paul Wordsworth</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kay, Jonathon" sort="Kay, Jonathon" uniqKey="Kay J" first="Jonathon" last="Kay">Jonathon Kay</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsia, Elizabeth" sort="Hsia, Elizabeth" uniqKey="Hsia E" first="Elizabeth" last="Hsia">Elizabeth Hsia</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Yiying" sort="Zhou, Yiying" uniqKey="Zhou Y" first="Yiying" last="Zhou">Yiying Zhou</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical University of Vienna/Hietzing Hospital, Vienna, Austria; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siri, Daniel" sort="Siri, Daniel" uniqKey="Siri D" first="Daniel" last="Siri">Daniel Siri</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furie, Richard" sort="Furie, Richard" uniqKey="Furie R" first="Richard" last="Furie">Richard Furie</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krasnow, Joel" sort="Krasnow, Joel" uniqKey="Krasnow J" first="Joel" last="Krasnow">Joel Krasnow</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alecock, Emma" sort="Alecock, Emma" uniqKey="Alecock E" first="Emma" last="Alecock">Emma Alecock</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alten, Rieke" sort="Alten, Rieke" uniqKey="Alten R" first="Rieke" last="Alten">Rieke Alten</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; CAICI Institute, Rosario, Argentina; NS-LIJ Health System, Lake Success, NY, USA; F. Hoffmann-La Roche, Nutley, NJ, USA; F. Hoffmann-La Roche, Welwyn, UK; Schlosspark Clinic, University of Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki-City, Japan; Clinical Research, Chugai Pharmaceutical Co., Ltd, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kawata, Yuichi" sort="Kawata, Yuichi" uniqKey="Kawata Y" first="Yuichi" last="Kawata">Yuichi Kawata</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki-City, Japan; Clinical Research, Chugai Pharmaceutical Co., Ltd, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aoki, Chieko" sort="Aoki, Chieko" uniqKey="Aoki C" first="Chieko" last="Aoki">Chieko Aoki</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki-City, Japan; Clinical Research, Chugai Pharmaceutical Co., Ltd, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mima, Toru" sort="Mima, Toru" uniqKey="Mima T" first="Toru" last="Mima">Toru Mima</name>
<affiliation wicri:level="3"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki-City, Japan; Clinical Research, Chugai Pharmaceutical Co., Ltd, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F." last="Van Vollenhoven">Ronald F. Van Vollenhoven</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nishimoto, Norihio" sort="Nishimoto, Norihio" uniqKey="Nishimoto N" first="Norihio" last="Nishimoto">Norihio Nishimoto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamanaka, Hisashi" sort="Yamanaka, Hisashi" uniqKey="Yamanaka H" first="Hisashi" last="Yamanaka">Hisashi Yamanaka</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Woodworth, Thasia" sort="Woodworth, Thasia" uniqKey="Woodworth T" first="Thasia" last="Woodworth">Thasia Woodworth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schiff, Michael H" sort="Schiff, Michael H" uniqKey="Schiff M" first="Michael H." last="Schiff">Michael H. Schiff</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E." last="Pope">Janet E. Pope</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Karolinska Institute, Stockholm, Sweden; Wakayama Medical University, Wakayama, Japan; Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; F. Hoffmann-La Roche, Welwyn, UK; University of Colorado School of Medicine, Denver, CO, USA; Royal Perth Hospital, Perth, WA, Australia; University of Western Ontario, London, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rubbert, Andrea" sort="Rubbert, Andrea" uniqKey="Rubbert A" first="Andrea" last="Rubbert">Andrea Rubbert</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Murphy, Frederick T" sort="Murphy, Frederick T" uniqKey="Murphy F" first="Frederick T." last="Murphy">Frederick T. Murphy</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Zhong" sort="Wu, Zhong" uniqKey="Wu Z" first="Zhong" last="Wu">Zhong Wu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
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<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Palo Alto, CA, USA; University Hospital of Cologne, Cologne, Germany; Rebecca MacDonald Ctr for Arthritis and Autoimmune Disease, Toronto, ON, Canada; Centocor RandD, Inc/University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Johnson and Johnson Pharmaceutical Services, Malvern, PA, USA; Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden; Altoona Center for Clinical Research, Duncansville, PA, USA; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
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<author><name sortKey="Kay, Jonathan" sort="Kay, Jonathan" uniqKey="Kay J" first="Jonathan" last="Kay">Jonathan Kay</name>
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<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
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<author><name sortKey="Wordsworth, Paul" sort="Wordsworth, Paul" uniqKey="Wordsworth P" first="Paul" last="Wordsworth">Paul Wordsworth</name>
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<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
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<author><name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
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<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
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<author><name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Zhou, Yiying" sort="Zhou, Yiying" uniqKey="Zhou Y" first="Yiying" last="Zhou">Yiying Zhou</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Shreekant, Parasuraman" sort="Shreekant, Parasuraman" uniqKey="Shreekant P" first="Parasuraman" last="Shreekant">Parasuraman Shreekant</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Nuffield Orthopaedic Centre, Oxford, UK; Centocor RandD, Inc./University of Pennsylvania School of Medicine, Malvern/Philadelphia, PA, USA; Medical University of Vienna, Vienna, Austria; Johnson and Johnson Pharmaceutical Services, LLC, Malvern, PA, USA; Mayo Clinic, Rochester, MN, USA; University Hospital Maastricht, Maastricht, Netherlands; Centocor Research and Development, Inc., Malvern, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J. J." last="Gomez-Reino">J. J. Gomez-Reino</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
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<author><name sortKey="Davies, C" sort="Davies, C" uniqKey="Davies C" first="C." last="Davies">C. Davies</name>
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<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
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<author><name sortKey="Alecock, E" sort="Alecock, E" uniqKey="Alecock E" first="E." last="Alecock">E. Alecock</name>
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<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
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<author><name sortKey="Rubbert Roth, A" sort="Rubbert Roth, A" uniqKey="Rubbert Roth A" first="A." last="Rubbert-Roth">A. Rubbert-Roth</name>
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<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emery, P" sort="Emery, P" uniqKey="Emery P" first="P." last="Emery">P. Emery</name>
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<wicri:regionArea>Medical University of Vienna, Vienna, Austria; Universidad de Santiago de Compostela, Santiago de Compostela, Spain; F. Hoffmann-La Roche, Welwyn, UK; University of Cologne, Cologne, Germany; St James' University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
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<series><title level="j">Rheumatology</title>
<idno type="ISSN">1462-0324</idno>
<idno type="eISSN">1462-0332</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2010-04">2010-04</date>
<biblScope unit="volume">49</biblScope>
<biblScope unit="supplement">suppl_1</biblScope>
<biblScope unit="page" from="89">i89</biblScope>
<biblScope unit="page" to="111">i111</biblScope>
</imprint>
<idno type="ISSN">1462-0324</idno>
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<front><div type="abstract">Background: UK guidelines and a `Rheumatology' editorial suggest that liver function tests (LFTs) alone remain a satisfactory method for methotrexate (MTX) monitoring in rheumatoid arthritis (RA). Recent literature also suggests no difference in hepatotoxity between MTX treated RA and psoriatic arthritis (PsA) patients. We describe 3 cases of liver fibrosis / cirrhosis missed by conventional monitoring. Methods: Case 1: 71 yr old female, RA 35 yrs. Presented 2005. Previous breast cancer. Alcohol < 1 unit/week. Rx MTX for 20 years, up to 25mg weekly. Leflunomide (Lef) 10 mg od added 3 mths previously. LFTs normal, P3NP 6.6. 2005-6 RA well controlled, normal LFTs. Repeat P3NP 2006 11.7. Liver ultrasound (US): normal echogenicity and hepatic and portal vein flow. Attempts to stop Lef were unsuccessful and led to use of rescue depomedrone. Developed diabetes. Sept 2007 LFTs normal, albumin 35. Feb 2008: admitted with ascites, ALT 41, albumin 31, bilirubin 24. CT liver normal, US suggested fatty change with normal portal flow. Biopsy showed established cirrhosis on a background of steatohepatitis. MTX and Lef stopped. June 2008: fatal pneumonia. Case 2: 69 yr old male. RA 2007; previous type II diabetes Rx insulin. On simvastatin. Alcohol < 1 unit/week. eGFR 60. LFTs normal. Rx MTX 12.5 mg/week + folic acid. July 2008 ALT 83: MTX ↓ 10 mg, Oct 2008 ALT 89: MTX ↓7.5 mg. Nov 2008 ALT 69. Dec 2008 - Aug 2009 ALT 70, 91, 67, 65, 52 (ie < x2 normal). Aug 2009 ALT 38, alb 27. Sept 2008 ALT 85, albumin 22, INR 1.7.US: shrunken liver. Full liver screen negative. Developed spontaneous bacterial peritonitis. Died Sept 2009. Results: Case 3: 63 yr old female, presented 1999. PsA diagnosed 1993, Rx MTX 7.5mg weekly. Alcohol < 1 unit/week. 1996 ‘routine’ liver biopsy performed (i.e. after 3 yrs MTX), result missing. 1997 US liver normal. Jan 1999: AST 69. Previous liver biopsy retrieved: steatosis + perivascular fibrosis. MTX stopped. LFTs normalized and remain normal. Conclusions: The risk of liver damage in some MTX treated RA and PsA patients may be higher than we think. Patients remain on MTX long term, may resume excess alcohol consumption and may develop concommitant non alcoholic fatty liver disease and steatohepatitis (NAFLD, NASH) during the course of their illness. Polypharmacy (case 1) and diabetes (cases 1 and 2) may be further risk factors. Normal LFTs and US may offer false reasurance. However, minor elevations of liver enzymes may point towards ongoing fibrosis (Case 2). P3NP is used in psoriasis but not in RA because of the confounding factors of disease activity and joint erosion. However, normal values may give some reassurance. US is unreliable as a guide to fibrosis, but more sensitive scans, including Fibroscan, offer promise. Our cases suggest that there may be at risk MTX treated RA and PsA patients who require more detailed liver monitoring. Disclosure statement: All authors have declared no conflicts of interest.</div>
</front>
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<name sortKey="Goel, Niti" sort="Goel, Niti" uniqKey="Goel N" first="Niti" last="Goel">Niti Goel</name>
<name sortKey="Gomez Reino, J J" sort="Gomez Reino, J J" uniqKey="Gomez Reino J" first="J. J." last="Gomez-Reino">J. J. Gomez-Reino</name>
<name sortKey="Gwynne, Catherine" sort="Gwynne, Catherine" uniqKey="Gwynne C" first="Catherine" last="Gwynne">Catherine Gwynne</name>
<name sortKey="Hassan, Waji" sort="Hassan, Waji" uniqKey="Hassan W" first="Waji" last="Hassan">Waji Hassan</name>
<name sortKey="Hessey, Eva" sort="Hessey, Eva" uniqKey="Hessey E" first="Eva" last="Hessey">Eva Hessey</name>
<name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D." last="Isaacs">John D. Isaacs</name>
<name sortKey="Jahreis, Angelika" sort="Jahreis, Angelika" uniqKey="Jahreis A" first="Angelika" last="Jahreis">Angelika Jahreis</name>
<name sortKey="Jones, Richard" sort="Jones, Richard" uniqKey="Jones R" first="Richard" last="Jones">Richard Jones</name>
<name sortKey="Joshi, Nilay" sort="Joshi, Nilay" uniqKey="Joshi N" first="Nilay" last="Joshi">Nilay Joshi</name>
<name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Kidd, Elizabeth" sort="Kidd, Elizabeth" uniqKey="Kidd E" first="Elizabeth" last="Kidd">Elizabeth Kidd</name>
<name sortKey="Kiely, Patrick D" sort="Kiely, Patrick D" uniqKey="Kiely P" first="Patrick D." last="Kiely">Patrick D. Kiely</name>
<name sortKey="King, Lloyd" sort="King, Lloyd" uniqKey="King L" first="Lloyd" last="King">Lloyd King</name>
<name sortKey="Kitas, George D" sort="Kitas, George D" uniqKey="Kitas G" first="George D." last="Kitas">George D. Kitas</name>
<name sortKey="Kivitz, Alan" sort="Kivitz, Alan" uniqKey="Kivitz A" first="Alan" last="Kivitz">Alan Kivitz</name>
<name sortKey="Lam, Manda" sort="Lam, Manda" uniqKey="Lam M" first="Manda" last="Lam">Manda Lam</name>
<name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<name sortKey="Langtree, Matthew" sort="Langtree, Matthew" uniqKey="Langtree M" first="Matthew" last="Langtree">Matthew Langtree</name>
<name sortKey="Lawson, Tom" sort="Lawson, Tom" uniqKey="Lawson T" first="Tom" last="Lawson">Tom Lawson</name>
<name sortKey="Ledingham, Joanna" sort="Ledingham, Joanna" uniqKey="Ledingham J" first="Joanna" last="Ledingham">Joanna Ledingham</name>
<name sortKey="Linton, Stuart" sort="Linton, Stuart" uniqKey="Linton S" first="Stuart" last="Linton">Stuart Linton</name>
<name sortKey="Loke, Yoon" sort="Loke, Yoon" uniqKey="Loke Y" first="Yoon" last="Loke">Yoon Loke</name>
<name sortKey="Macgregor, Alex" sort="Macgregor, Alex" uniqKey="Macgregor A" first="Alex" last="Macgregor">Alex Macgregor</name>
<name sortKey="Makadsi, Raad" sort="Makadsi, Raad" uniqKey="Makadsi R" first="Raad" last="Makadsi">Raad Makadsi</name>
<name sortKey="Malaiya, Ritu" sort="Malaiya, Ritu" uniqKey="Malaiya R" first="Ritu" last="Malaiya">Ritu Malaiya</name>
<name sortKey="Malipeddi, Aruna" sort="Malipeddi, Aruna" uniqKey="Malipeddi A" first="Aruna" last="Malipeddi">Aruna Malipeddi</name>
<name sortKey="Malipeddi, Aruna S" sort="Malipeddi, Aruna S" uniqKey="Malipeddi A" first="Aruna S." last="Malipeddi">Aruna S. Malipeddi</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Marks, Jonathan L" sort="Marks, Jonathan L" uniqKey="Marks J" first="Jonathan L." last="Marks">Jonathan L. Marks</name>
<name sortKey="Mcdowell, Jackie A" sort="Mcdowell, Jackie A" uniqKey="Mcdowell J" first="Jackie A." last="Mcdowell">Jackie A. Mcdowell</name>
<name sortKey="Mckay, Neil" sort="Mckay, Neil" uniqKey="Mckay N" first="Neil" last="Mckay">Neil Mckay</name>
<name sortKey="Mease, Philip" sort="Mease, Philip" uniqKey="Mease P" first="Philip" last="Mease">Philip Mease</name>
<name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J." last="Mease">Philip J. Mease</name>
<name sortKey="Morgan, Darrell" sort="Morgan, Darrell" uniqKey="Morgan D" first="Darrell" last="Morgan">Darrell Morgan</name>
<name sortKey="Mossadegh, Somayyeh" sort="Mossadegh, Somayyeh" uniqKey="Mossadegh S" first="Somayyeh" last="Mossadegh">Somayyeh Mossadegh</name>
<name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name>
<name sortKey="Neame, Rebecca" sort="Neame, Rebecca" uniqKey="Neame R" first="Rebecca" last="Neame">Rebecca Neame</name>
<name sortKey="Nesbitt, Andrew" sort="Nesbitt, Andrew" uniqKey="Nesbitt A" first="Andrew" last="Nesbitt">Andrew Nesbitt</name>
<name sortKey="Ostor, Andrew J" sort="Ostor, Andrew J" uniqKey="Ostor A" first="Andrew J." last="Östör">Andrew J. Östör</name>
<name sortKey="Parker, Gerry" sort="Parker, Gerry" uniqKey="Parker G" first="Gerry" last="Parker">Gerry Parker</name>
<name sortKey="Parton, Ted" sort="Parton, Ted" uniqKey="Parton T" first="Ted" last="Parton">Ted Parton</name>
<name sortKey="Quinn, Mark A" sort="Quinn, Mark A" uniqKey="Quinn M" first="Mark A." last="Quinn">Mark A. Quinn</name>
<name sortKey="Rachapalli, Satish M" sort="Rachapalli, Satish M" uniqKey="Rachapalli S" first="Satish M." last="Rachapalli">Satish M. Rachapalli</name>
<name sortKey="Read, Simon" sort="Read, Simon" uniqKey="Read S" first="Simon" last="Read">Simon Read</name>
<name sortKey="Rees, David H" sort="Rees, David H" uniqKey="Rees D" first="David H." last="Rees">David H. Rees</name>
<name sortKey="Reynard, Mark" sort="Reynard, Mark" uniqKey="Reynard M" first="Mark" last="Reynard">Mark Reynard</name>
<name sortKey="Rhys Dillon, Brian" sort="Rhys Dillon, Brian" uniqKey="Rhys Dillon B" first="Brian" last="Rhys Dillon">Brian Rhys Dillon</name>
<name sortKey="Rubbert Roth, A" sort="Rubbert Roth, A" uniqKey="Rubbert Roth A" first="A." last="Rubbert-Roth">A. Rubbert-Roth</name>
<name sortKey="Rubbert Roth, Andrea" sort="Rubbert Roth, Andrea" uniqKey="Rubbert Roth A" first="Andrea" last="Rubbert-Roth">Andrea Rubbert-Roth</name>
<name sortKey="Sandoo, Aamer" sort="Sandoo, Aamer" uniqKey="Sandoo A" first="Aamer" last="Sandoo">Aamer Sandoo</name>
<name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
<name sortKey="Schiff, Michael" sort="Schiff, Michael" uniqKey="Schiff M" first="Michael" last="Schiff">Michael Schiff</name>
<name sortKey="Shaw, Tim" sort="Shaw, Tim" uniqKey="Shaw T" first="Tim" last="Shaw">Tim Shaw</name>
<name sortKey="Sheikzadeh, Ali" sort="Sheikzadeh, Ali" uniqKey="Sheikzadeh A" first="Ali" last="Sheikzadeh">Ali Sheikzadeh</name>
<name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
<name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J. S." last="Smolen">J. S. Smolen</name>
<name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<name sortKey="Smolen, Josef" sort="Smolen, Josef" uniqKey="Smolen J" first="Josef" last="Smolen">Josef Smolen</name>
<name sortKey="Stavropoulos Kalinoglou, Antonios" sort="Stavropoulos Kalinoglou, Antonios" uniqKey="Stavropoulos Kalinoglou A" first="Antonios" last="Stavropoulos-Kalinoglou">Antonios Stavropoulos-Kalinoglou</name>
<name sortKey="Stohl, William" sort="Stohl, William" uniqKey="Stohl W" first="William" last="Stohl">William Stohl</name>
<name sortKey="Strand, V" sort="Strand, V" uniqKey="Strand V" first="V." last="Strand">V. Strand</name>
<name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P." last="Tak">Paul P. Tak</name>
<name sortKey="Tak, Paul P" sort="Tak, Paul P" uniqKey="Tak P" first="Paul P." last="Tak">Paul P. Tak</name>
<name sortKey="Taylor, Peter C" sort="Taylor, Peter C" uniqKey="Taylor P" first="Peter C." last="Taylor">Peter C. Taylor</name>
<name sortKey="Tyrrell, Helen" sort="Tyrrell, Helen" uniqKey="Tyrrell H" first="Helen" last="Tyrrell">Helen Tyrrell</name>
<name sortKey="Vagadia, Vipul" sort="Vagadia, Vipul" uniqKey="Vagadia V" first="Vipul" last="Vagadia">Vipul Vagadia</name>
<name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Desiree" last="Van Der Heijde">Desiree Van Der Heijde</name>
<name sortKey="Van Vollenhoven, Raymond" sort="Van Vollenhoven, Raymond" uniqKey="Van Vollenhoven R" first="Raymond" last="Van Vollenhoven">Raymond Van Vollenhoven</name>
<name sortKey="Watson, Kathryn" sort="Watson, Kathryn" uniqKey="Watson K" first="Kathryn" last="Watson">Kathryn Watson</name>
<name sortKey="Westlake, Sarah L" sort="Westlake, Sarah L" uniqKey="Westlake S" first="Sarah L." last="Westlake">Sarah L. Westlake</name>
<name sortKey="Williams, Emma" sort="Williams, Emma" uniqKey="Williams E" first="Emma" last="Williams">Emma Williams</name>
<name sortKey="Williams, Richard B" sort="Williams, Richard B" uniqKey="Williams R" first="Richard B." last="Williams">Richard B. Williams</name>
<name sortKey="Willott, Ruth" sort="Willott, Ruth" uniqKey="Willott R" first="Ruth" last="Willott">Ruth Willott</name>
<name sortKey="Wright, David" sort="Wright, David" uniqKey="Wright D" first="David" last="Wright">David Wright</name>
<name sortKey="Yocum, David" sort="Yocum, David" uniqKey="Yocum D" first="David" last="Yocum">David Yocum</name>
<name sortKey="Young, Adam" sort="Young, Adam" uniqKey="Young A" first="Adam" last="Young">Adam Young</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name>
</noRegion>
<name sortKey="Abud Mendoza, Carlos" sort="Abud Mendoza, Carlos" uniqKey="Abud Mendoza C" first="Carlos" last="Abud-Mendoza">Carlos Abud-Mendoza</name>
<name sortKey="Becker, Jean Claude" sort="Becker, Jean Claude" uniqKey="Becker J" first="Jean-Claude" last="Becker">Jean-Claude Becker</name>
<name sortKey="Chen, Naijun" sort="Chen, Naijun" uniqKey="Chen N" first="Naijun" last="Chen">Naijun Chen</name>
<name sortKey="Cifaldi, Mary" sort="Cifaldi, Mary" uniqKey="Cifaldi M" first="Mary" last="Cifaldi">Mary Cifaldi</name>
<name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<name sortKey="Gotlieb, Larry" sort="Gotlieb, Larry" uniqKey="Gotlieb L" first="Larry" last="Gotlieb">Larry Gotlieb</name>
<name sortKey="Kremer, Joel M" sort="Kremer, Joel M" uniqKey="Kremer J" first="Joel M." last="Kremer">Joel M. Kremer</name>
<name sortKey="Malaise, Michel" sort="Malaise, Michel" uniqKey="Malaise M" first="Michel" last="Malaise">Michel Malaise</name>
<name sortKey="Roy, Sanjoy" sort="Roy, Sanjoy" uniqKey="Roy S" first="Sanjoy" last="Roy">Sanjoy Roy</name>
<name sortKey="Russell, Anthony S" sort="Russell, Anthony S" uniqKey="Russell A" first="Anthony S." last="Russell">Anthony S. Russell</name>
<name sortKey="Szechinski, Jacek" sort="Szechinski, Jacek" uniqKey="Szechinski J" first="Jacek" last="Szechinski">Jacek Szechinski</name>
<name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name>
<name sortKey="Wu, George" sort="Wu, George" uniqKey="Wu G" first="George" last="Wu">George Wu</name>
</country>
<country name="Égypte"><noRegion><name sortKey="El Miedany, Yasser" sort="El Miedany, Yasser" uniqKey="El Miedany Y" first="Yasser" last="El Miedany">Yasser El Miedany</name>
</noRegion>
<name sortKey="El Gaafary, Maha" sort="El Gaafary, Maha" uniqKey="El Gaafary M" first="Maha" last="El Gaafary">Maha El Gaafary</name>
<name sortKey="Palmer, Deborah" sort="Palmer, Deborah" uniqKey="Palmer D" first="Deborah" last="Palmer">Deborah Palmer</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Morcos, Peter N" sort="Morcos, Peter N" uniqKey="Morcos P" first="Peter N." last="Morcos">Peter N. Morcos</name>
</noRegion>
<name sortKey="Grange, Susan" sort="Grange, Susan" uniqKey="Grange S" first="Susan" last="Grange">Susan Grange</name>
<name sortKey="Isaacs, John D" sort="Isaacs, John D" uniqKey="Isaacs J" first="John D." last="Isaacs">John D. Isaacs</name>
<name sortKey="Olech, Ewa" sort="Olech, Ewa" uniqKey="Olech E" first="Ewa" last="Olech">Ewa Olech</name>
<name sortKey="Schmitt, Christophe" sort="Schmitt, Christophe" uniqKey="Schmitt C" first="Christophe" last="Schmitt">Christophe Schmitt</name>
<name sortKey="Zhang, Xiaoping" sort="Zhang, Xiaoping" uniqKey="Zhang X" first="Xiaoping" last="Zhang">Xiaoping Zhang</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name>
</region>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Luijtens, Kristel" sort="Luijtens, Kristel" uniqKey="Luijtens K" first="Kristel" last="Luijtens">Kristel Luijtens</name>
<name sortKey="Massarotti, Elena" sort="Massarotti, Elena" uniqKey="Massarotti E" first="Elena" last="Massarotti">Elena Massarotti</name>
<name sortKey="Schwartzman, Sergio" sort="Schwartzman, Sergio" uniqKey="Schwartzman S" first="Sergio" last="Schwartzman">Sergio Schwartzman</name>
<name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Desiree" last="Van Der Heijde">Desiree Van Der Heijde</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name>
</region>
<name sortKey="Armstrong, Gillian K" sort="Armstrong, Gillian K" uniqKey="Armstrong G" first="Gillian K." last="Armstrong">Gillian K. Armstrong</name>
<name sortKey="Baldassare, Andrew R" sort="Baldassare, Andrew R" uniqKey="Baldassare A" first="Andrew R." last="Baldassare">Andrew R. Baldassare</name>
<name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name>
<name sortKey="Blesch, Anne" sort="Blesch, Anne" uniqKey="Blesch A" first="Anne" last="Blesch">Anne Blesch</name>
<name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
<name sortKey="Buchanan, Jacqueline" sort="Buchanan, Jacqueline" uniqKey="Buchanan J" first="Jacqueline" last="Buchanan">Jacqueline Buchanan</name>
<name sortKey="Curtis, Jeffrey R" sort="Curtis, Jeffrey R" uniqKey="Curtis J" first="Jeffrey R." last="Curtis">Jeffrey R. Curtis</name>
<name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
<name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
<name sortKey="Doyle, Mittie K" sort="Doyle, Mittie K" uniqKey="Doyle M" first="Mittie K." last="Doyle">Mittie K. Doyle</name>
<name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name>
<name sortKey="Farmer, Pamela" sort="Farmer, Pamela" uniqKey="Farmer P" first="Pamela" last="Farmer">Pamela Farmer</name>
<name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<name sortKey="Fleischmann, Roy M" sort="Fleischmann, Roy M" uniqKey="Fleischmann R" first="Roy M." last="Fleischmann">Roy M. Fleischmann</name>
<name sortKey="Furie, Richard" sort="Furie, Richard" uniqKey="Furie R" first="Richard" last="Furie">Richard Furie</name>
<name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name>
<name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
<name sortKey="Genovese, Mark C" sort="Genovese, Mark C" uniqKey="Genovese M" first="Mark C." last="Genovese">Mark C. Genovese</name>
<name sortKey="Guerette, Benoit" sort="Guerette, Benoit" uniqKey="Guerette B" first="Benoît" last="Guérette">Benoît Guérette</name>
<name sortKey="Hsia, Elizabeth" sort="Hsia, Elizabeth" uniqKey="Hsia E" first="Elizabeth" last="Hsia">Elizabeth Hsia</name>
<name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name>
<name sortKey="Kavanaugh, Arthur" sort="Kavanaugh, Arthur" uniqKey="Kavanaugh A" first="Arthur" last="Kavanaugh">Arthur Kavanaugh</name>
<name sortKey="Kay, Jonathan" sort="Kay, Jonathan" uniqKey="Kay J" first="Jonathan" last="Kay">Jonathan Kay</name>
<name sortKey="Kay, Jonathon" sort="Kay, Jonathon" uniqKey="Kay J" first="Jonathon" last="Kay">Jonathon Kay</name>
<name sortKey="Keystone, Edward" sort="Keystone, Edward" uniqKey="Keystone E" first="Edward" last="Keystone">Edward Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name>
<name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name>
<name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name>
<name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewe">Robert Landewe</name>
<name sortKey="Lavie, Frederic" sort="Lavie, Frederic" uniqKey="Lavie F" first="Frederic" last="Lavie">Frederic Lavie</name>
<name sortKey="Lehane, Patricia B" sort="Lehane, Patricia B" uniqKey="Lehane P" first="Patricia B." last="Lehane">Patricia B. Lehane</name>
<name sortKey="Linnik, Matthew" sort="Linnik, Matthew" uniqKey="Linnik M" first="Matthew" last="Linnik">Matthew Linnik</name>
<name sortKey="Long, Simon G" sort="Long, Simon G" uniqKey="Long S" first="Simon G." last="Long">Simon G. Long</name>
<name sortKey="Macey, Katherine" sort="Macey, Katherine" uniqKey="Macey K" first="Katherine" last="Macey">Katherine Macey</name>
<name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name>
<name sortKey="Murphy, Frederick T" sort="Murphy, Frederick T" uniqKey="Murphy F" first="Frederick T." last="Murphy">Frederick T. Murphy</name>
<name sortKey="Parasuraman, Shreekant" sort="Parasuraman, Shreekant" uniqKey="Parasuraman S" first="Shreekant" last="Parasuraman">Shreekant Parasuraman</name>
<name sortKey="Patra, Kaushik" sort="Patra, Kaushik" uniqKey="Patra K" first="Kaushik" last="Patra">Kaushik Patra</name>
<name sortKey="Purcaru, Oana" sort="Purcaru, Oana" uniqKey="Purcaru O" first="Oana" last="Purcaru">Oana Purcaru</name>
<name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
<name sortKey="Rahman, Mahboob U" sort="Rahman, Mahboob U" uniqKey="Rahman M" first="Mahboob U." last="Rahman">Mahboob U. Rahman</name>
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<name sortKey="Nishimoto, Norihiro" sort="Nishimoto, Norihiro" uniqKey="Nishimoto N" first="Norihiro" last="Nishimoto">Norihiro Nishimoto</name>
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   |texte=   Rheumatoid Arthritis: Treatment [151–201]
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Rheumatoid Arthritis: Treatment [151–201]

Rheumatoid Arthritis: Treatment [151–201]

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